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Humoral IgG1 responses to tumor antigens underpin clinical outcomes in immune checkpoint blockade
Abstract Tumor-infiltrating T cells have been the primary focus of cancer immunotherapy; however, accumulating evidence points to a critical role for B cells and plasma cells in shaping responses to i …
High-throughput spheroid-based assay for functional breast cancer precision medicine facilitated by deep learning
Abstract Background Despite rapid advances in treatment, breast cancer remains the leading cause of cancer mortality in women, with triple negative breast cancers having a particularly poor prognosis. …
High-resolution lifestyle profiling and metabolic subphenotypes of type 2 diabetes
Distinct metabolic susceptibilities (beta-cell dysfunction, insulin resistance (IR), and impaired incretin response) underlie type 2 diabetes (T2D). However, their relationships with habitual lifestyl …
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