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Nous-209 neoantigen vaccine for cancer prevention in Lynch syndrome carriers: a phase 1b/2 trial
Abstract Cancer interception is a preventative approach aiming to reduce cancer incidence by targeting precancers and early-stage cancers. Lynch syndrome (LS) is a prevalent hereditary cancer syndrome …
Nalmefene and naltrexone reduce alcohol intake via selective efficacy in subpopulations distinguished by behavioral and blood-based biomarkers
Nalmefene and naltrexone are two drug treatments for alcohol use disorder, but disagreement exists on which is more effective. Despite ongoing controversy, treatment outcomes have only been compared a …
Nonlinear dynamics of multi-omics profiles during human aging
Aging is a complex process associated with nearly all diseases. Understanding the molecular changes underlying aging and identifying therapeutic targets for aging-related diseases are crucial for incr …
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